Thyroid autoimmunity and miscarriage
| Autor: | Mark F. Prummel, Wilmar M. Wiersinga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland Autoimmunity Iodide Peroxidase Autoimmune Diseases Miscarriage Endocrinology Hypothyroidism Pregnancy Thyroid peroxidase Internal medicine Odds Ratio medicine Humans Euthyroid Autoantibodies biology business.industry Thyroid Age Factors General Medicine Odds ratio medicine.disease Confidence interval Anti-thyroid autoantibodies Abortion Spontaneous Pregnancy Complications medicine.anatomical_structure biology.protein Female business Hormone |
| Zdroj: | European journal of endocrinology / European Federation of Endocrine Societies. 150(6):751-755 |
| ISSN: | 0804-4643 |
| DOI: | 10.1530/eje.0.1500751 |
| Popis: | To ascertain the strength of the association between thyroid autoimmunity and miscarriage, we performed a meta-analysis of both case-control and longitudinal studies performed since 1990 when this association was first described. A clear association between the presence of thyroid antibodies and miscarriage was found with an odds ratio (OR) of 2.73 (95 % confidence interval (CI), 2.20-3.40) in eight case-control and ten longitudinal (OR, 2.30; 95 % CI, 1.80-2.95) studies. This association may be explained by a heightened autoimmune state affecting the fetal allograft, of which thyroid antibodies are just a marker. Alternatively, the association can be partly explained by the slightly higher age of women with antibodies compared with those without (mean+/-S.D. age difference, 0.7+/-1.0 years; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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