Bacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Disease
| Autor: | Walter K. Kremers, Tetyana V. Masyuk, Naoki Takahashi, Sarah R. Senum, Peter C. Harris, Nicholas F. LaRusso, Matthew D. Griffin, David M. Nagorney, Patrick S. Kamath, Marie E. Edwards, Vicente E. Torres, Marie C. Hogan, Kotaro Yoshida, Ziad M. El-Zoghby, Andrew J. Metzger, Lisa E. Vaughan, William P. Martin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Autosomal dominant polycystic kidney disease AST aspartate aminotransferase 030204 cardiovascular system & hematology ICD-10 International Classification of Diseases Tenth Revision Gastroenterology Hepatic cysts PET positron emission tomography 03 medical and health sciences Liver disease 0302 clinical medicine Internal medicine ALT alanine aminotransferase medicine PLD polycystic liver disease 030212 general & internal medicine ADPLD autosomal dominant polycystic liver disease lcsh:R5-920 Endoscopic retrograde cholangiopancreatography medicine.diagnostic_test Intrahepatic bile duct dilatation ALP alkaline phosphatase business.industry Polycystic liver disease ICD-9 International Classification of Diseases Ninth Revision Gallstones Odds ratio T2DM type 2 diabetes mellitus medicine.disease Diverticulosis CT computed tomography OR odds ratio Recurrent cholangitis ADPKD autosomal dominant polycystic kidney disease Cholecystectomy Original Article business lcsh:Medicine (General) MRI magnetic resonance imaging MCR Mayo Clinic Rochester MN ERCP endoscopic retrograde cholangiopancreatography |
| Zdroj: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 3, Iss 2, Pp 149-159 (2019) Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| ISSN: | 2542-4548 |
| Popis: | Objective: To describe first episodes of bacterial cholangitis complicating autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD) and to identify risk factors for cholangitis episodes among patients with ADPKD-associated polycystic liver disease (PLD). Patients and Methods: We searched the electronic medical records at our tertiary referral center for episodes of cholangitis in patients with ADPKD or ADPLD from January 1, 1996, through June 30, 2017. Cases were categorized as suspected or definite cholangitis by expert review. Clinical, laboratory, and radiologic data were manually abstracted. A nested case-control study was conducted to investigate risk factors for cholangitis in patients with ADPKD. Results: We identified 29 cases of definite or suspected cholangitis complicating PLD (24 with ADPKD-associated PLD and 5 with ADPLD). Among patients with definite cholangitis in ADPKD-associated PLD (n=19) vs ADPLD (n=4), the mean ± SD age was 62.4±12.2 vs 55.1±8.6 years, and 9 (47.4%) vs 0 (0%), respectively, were male. The odds of gallstones (odds ratio [OR], 21.6; 95% CI, 3.17-927; P |
| Databáze: | OpenAIRE |
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