Treatment of hepatic carcinoma by low-frequency ultrasound and microbubbles: A case report
| Autor: | Zhi Yong Shen, Kang Shen, Ming Feng Wu, Yi‑Xin Zhang, Gan Lin Xia |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
therapy
Cancer Research Pathology medicine.medical_specialty Oncogene low-frequency ultrasound business.industry Therapeutic effect Ultrasound Cancer Articles hepatic tumor medicine.disease Molecular medicine microbubbles medicine.anatomical_structure cavitation Oncology In vivo Microbubbles Medicine business Nuclear medicine Lymph node |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2014.2812 |
| Popis: | In vitro and in vivo studies have identified that low-frequency ultrasound (US) and microbubbles (MBs) mediate tumor inhibitory effects. However, the application of US in the clinical setting remains unclear. The aim of the present study was to investigate the clinically therapeutic effect of 20 kHz US in combination with MBs for the treatment of hepatic carcinoma. A 71-year-old male with a hepatic malignant tumor was admitted to Nantong University Affiliated Nantong Tumor Hospital (Nantong, China). The patient was subsequently sonicated with 20 kHz US and MBs over a period of five days. The low-frequency US parameters were set at 20 kHz, 2 W/cm2, duty cycle 40% (on 2 sec, off 3 sec) for a duration of 5 min each day for a total of five days. Computed tomography (CT), contrast-enhanced US (CEUS) and carbohydrate antigen 19-9 (CA19-9) tests were performed to evaluate the therapeutic effects. Although the tumor size increased marginally on CT from 5.4 to 5.6 cm after US treatment, the intensity and enhanced-areas on the CT scans and CEUS decreased. The abdominal lymph node decreased in size, from 2.2 to 1.9 cm, and CA19-9 levels decreased from the pretreatment value of 2,007 to 734 U/ml. Therapy with low-frequency US combined with MBs may exhibit an antivasculature effect and may be used as a palliative treatment for patients with unresectable hepatic malignant tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|