In vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep
| Autor: | Guillermo Leon Virkel, Carlos Lanusse, Paula Viviani, Lívio Martins Costa, Victoria Miró, Adrian Luis Lifschitz, Carolina Rocha |
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| Rok vydání: | 2019 |
| Předmět: |
Health
Toxicology and Mutagenesis Monoterpene Biology Toxicology 030226 pharmacology & pharmacy Biochemistry Albendazole 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine parasitic diseases medicine HEPATIC METABOLISM Anthelmintic Thymol THYMOL Pharmacology Traditional medicine Ciencias Veterinarias General Medicine Oxygenation biology.organism_classification In vitro Nematode SHEEP chemistry CIENCIAS AGRÍCOLAS 030220 oncology & carcinogenesis ALBENDAZOLE Drug metabolism medicine.drug |
| Zdroj: | Xenobiotica. 50:408-414 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.1080/00498254.2019.1644390 |
| Popis: | Combinations of bioactive phytochemicals with synthetic compounds have been suggested as promissory tools for the improvement of nematode control in livestock. Bioactive phytochemicals may interfere with the activity of drug-metabolizing enzymes and delay the metabolic conversion of anthelmintics into less potent metabolites. This research assessed the effect of the monoterpene thymol (TML) on the in vitro hepatic metabolism of the anthelmintic albendazole (ABZ) in sheep. Liver microsomes from four (4) Texel lambs were incubated with ABZ (50 µM) in absence or in presence of TML (0.05?10 mM). The concentration of TML producing a 50% decrease in ABZ S-oxygenation (IC50) was 13.5 mM. The FMO-dependent S-oxygenation of ABZ was markedly inhibited by the monoterpene (54.1 ± 11.6%, p |
| Databáze: | OpenAIRE |
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