Refeeding syndrome is associated with increased mortality in malnourished medical inpatients: Secondary analysis of a randomized trial
| Autor: | Ramona Hummel, Manuela Deiss, Pascal Tribolet, Natalie Friedli, Filomena Gomes, Jonas Odermatt, Susan Felder, Martina Geiser, Philipp Schuetz, Zeno Stanga, Milena Kloter, Rebecca Fehr, Jessica Baumann, Beat Mueller, Valerie Baechli |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty genetic structures 610 Medicine & health Context (language use) law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Risk Factors Internal medicine Clinical endpoint medicine Odds Ratio Humans 030212 general & internal medicine Medical nutrition therapy Prospective Studies Refeeding Syndrome Prospective cohort study skin and connective tissue diseases Survival rate Aged 2. Zero hunger Aged 80 and over hypophosphatemia Inpatients business.industry Nutritional Support Mortality rate Malnutrition effort trial General Medicine Odds ratio Clinical Trial/Experimental Study Middle Aged Survival Rate 030220 oncology & carcinogenesis Female electrolyte disturbances business nutritional therapy Research Article |
| Zdroj: | Medicine Friedli, Natalie; Baumann, Jessica; Hummel, Ramona; Kloter, Milena; Odermatt, Jonas; Fehr, Rebecca; Felder, Susan; Baechli, Valerie; Geiser, Martina; Deiss, Manuela; Tribolet, Pascal; Gomes, Filomena; Mueller, Beat; Stanga, Zeno; Schuetz, Philipp (2020). Refeeding syndrome is associated with increased mortality in malnourished medical inpatients: Secondary analysis of a randomized trial. Medicine, 99(1), e18506. Lippincott Williams & Wilkins 10.1097/MD.0000000000018506 |
| ISSN: | 1536-5964 |
| DOI: | 10.1097/MD.0000000000018506 |
| Popis: | BACKGROUND Whether the occurrence of refeeding syndrome (RFS), a metabolic condition characterized by electrolyte shifts after initiation of nutritional therapy, has a negative impact on clinical outcomes remains ill-defined. We prospectively investigated a subgroup of patients included in a multicentre, nutritional trial (EFFORT) for the occurrence of RFS. METHODS In this secondary analysis of a randomized-controlled trial investigating the effects of nutritional support in malnourished medical inpatients, we prospectively screened patients for RFS and classified them as "RFS confirmed" and "RFS not confirmed" based on predefined criteria (i.e. electrolyte shifts, clinical symptoms, clinical context, and patient history). We assessed associations of RFS and mortality within 180 days (primary endpoint) and other secondary endpoints using multivariable regression analysis. RESULTS Among 967 included patients, RFS was confirmed in 141 (14.6%) patients. Compared to patients with no evidence for RFS, patients with confirmed RFS had significantly increased 180-days mortality rates (42/141 (29.8%) vs 181/826 (21.9%), adjusted odds ratio (OR) 1.53 (95% CI 1.02 to 2.29), P |
| Databáze: | OpenAIRE |
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