Plasma levels of adipokines in patients with Alzheimer's disease - where is the 'breaking point' in Alzheimer's disease pathogenesis?
| Autor: | M. Vaňková, Hana Vaňková, Gabriela Vacinova, Běla Bendlová, Josef Vcelak, Robert Rusina, Eva Jarolímová, Iva Holmerová, D. Vejražková, P Lukasova |
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| Rok vydání: | 2020 |
| Předmět: |
Leptin
Male medicine.medical_specialty Physiology Adipokine 030209 endocrinology & metabolism Disease Pathogenesis 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Internal medicine medicine Humans Cognitive decline Adiponectin business.industry Neuropsychology General Medicine Plasma levels Articles Middle Aged Endocrinology Case-Control Studies Complement Factor D Female business 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Physiol Res |
| ISSN: | 1802-9973 |
| Popis: | Peripheral insulin resistance is associated with decreasing adiponectin and increasing leptin plasma levels, and also with cognitive decline. The effects of adipokines on brain function have been published from both animal and human studies. In particular, the influence of leptin and adiponectin on the development of Alzheimer’s disease (AD) has been extensively investigated. However, the association between adipsin and AD is as yet unknown. In 37 patients with AD and 65 controls that followed the same study protocol, we tested whether adiponectin, leptin, and adipsin could be used as biomarkers in the early stages of AD. In contrast with conclusions of cognition studies in insulin resistant states, our study found a correlation of impaired neuropsychological performance with increasing adiponectin and decreasing leptin in AD patients. Nevertheless, no significant differences between patients and controls were found. AD women had significantly increased adipsin compared to controls, and there was a positive correlation of adipsin with age and disease duration. Although adipokines do not appear to be suitable biomarkers for early AD diagnosis, they certainly play a role in the pathogenesis of AD. Further studies will be needed to explain the cause of the adipokine “breaking point” that leads to the pathogenesis of overt AD. |
| Databáze: | OpenAIRE |
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