Two-year prospective study of single infections and co-infections by respiratory syncytial virus and viruses identified recently in infants with acute respiratory disease
| Autor: | Egidio Romero, Patrizia Cambieri, Gianluigi Gargantini, Stefano Berrè, M. Debiaggi, Massimo Clementi, Michela Sampaolo, Filippo Canducci, Cristina Terulla, Maria Chiara Marinozzi |
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| Přispěvatelé: | Canducci, F, Debiaggi, M, Sampaolo, M, Marinozzi, Mc, Berrè, S, Terulla, C, Gargantini, G, Cambieri, P, Romero, E, Clementi, Massimo |
| Rok vydání: | 2008 |
| Předmět: |
Male
viruses Molecular Sequence Data coronavirus Comorbidity Respiratory Syncytial Virus Infections medicine.disease_cause Virus Article bocavirus Parvoviridae Infections Nidovirales Virology respiratory viruses Genotype medicine Prevalence Coronaviridae Humans Prospective Studies Respiratory system Pathogen Respiratory Tract Infections Coronavirus Paramyxoviridae Infections biology Human bocavirus Infant Newborn virus diseases Infant RSV Sequence Analysis DNA biology.organism_classification Respiratory Syncytial Viruses Infectious Diseases Italy Child Preschool Immunology DNA Viral hMPV Pharynx RNA Viral Female Metapneumovirus Coronavirus Infections Research Article |
| Zdroj: | Journal of Medical Virology |
| Popis: | A prospective 2‐year analysis including 322 infant patients with acute respiratory disease (ARD) hospitalized in a pediatric department in northern Italy was carried out to evaluate the role as respiratory pathogens or co‐pathogens of recently identified viruses. The presence of respiratory syncitial virus (RSV), human Metapneumoviruses (hMPVs), human Bocaviruses (hBoVs), and human Coronaviruses (hCoVs) was assayed by molecular detection and clinical symptoms evaluated. Nasopharyngeal aspirates from 150 of the 322 infants (46.6%) tested positive for at least one pathogen. Ninety samples (28.0%) tested positive for RSV RNA (61.5% genotype A and 38.5% genotype B), 46 (14.3%) for hMPV RNA (71.7% subtype A and 28.3% subtype B), 28 (8.7%) for hCoV RNA (39.3% hCoV‐OC43, 35.7% hCoV‐NL63, 21.4% hCoV‐HKU1, and 3.6% hCoV‐229E), and 7 (2.2%) for hBoV DNA (of the 6 typed, 50% subtype 1 and 50% subtype 2); 21/150 samples revealed the presence of 2 or more viruses. Co‐infection rates were higher for hMPVs, hCoVs, and hBoV (38.3%, 46.4%, and 57.1%,) and lower for RSV (23.3%). RSV was associated with the presence of complications (P |
| Databáze: | OpenAIRE |
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