Hemolytic Mechanism in Sickle Cell-Hgb C Disease
| Autor: | Donald L. Rucknagel, Robert Jim, Amoz I. Chernoff |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
Red Cell
business.industry Cell Erythrocytes Abnormal Anemia Spleen Anemia Sickle Cell Disease Haemolysis medicine.disease General Biochemistry Genetics and Molecular Biology Hemolysis Hemoglobins medicine.anatomical_structure hemic and lymphatic diseases Immunology medicine Humans Anemia sickle-cell Hemoglobin business |
| Zdroj: | Experimental Biology and Medicine. 90:547-550 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-90-22095 |
| Popis: | SummaryRed cells from 3 patients with sickle cell-Hgb C disease transfused into normal individuals with and without a spleen, were found to have a survival time of approximately 50 days. The spleen, therefore, does not appear to have a critical role in the hemolysis occurring in this disease. Possible mechanisms for the red cell destruction, based on the per cent of Hgb S present, as well as the role of the spleen during periods of crisis, are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|