On-Demand Drug Delivery System Using Micro-organogels with Gold Nanorods
| Autor: | Jin Yang Kang, Myoung-Hwan Park, Soojung Yang, Honglual Park |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
Materials science Nir light Nonsteroidal media_common.quotation_subject Organic Chemistry Flurbiprofen Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry On demand Drug Discovery Drug delivery medicine Nanorod 0210 nano-technology Drug carrier media_common medicine.drug |
| Zdroj: | ACS Medicinal Chemistry Letters. 7:1087-1091 |
| ISSN: | 1948-5875 |
| DOI: | 10.1021/acsmedchemlett.6b00293 |
| Popis: | In this study, we designed a biocompatible drug carrier: micro-organogels prepared by emulsification using vegetable oils and self-assembled gelator fibers. Flurbiprofen was chosen as a hydrophobic model drug and is classified as a nonsteroidal anti-inflammatory drug. In the absence of NIR light, flurbiprofen encapsulated in micro-organogels with gold nanorods (GNRs) was released slowly, while release was accelerated in the presence of NIR light due to the increase in the temperature surrounding the GNRs that transforms the gels into liquid. These results suggest that our system can be efficiently used as a versatile scaffold for on-demand drug delivery systems. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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