| Autor: |
Chelsea S. Hamill, Richard Grant Muller, Kate Clancy, Brandon Vu, Shanying Gui, Jason Eric Thuener, Jay Wasman, Shawn Li, Nicole Fowler, Rod Rezaee, Pierre Lavertu, Theodoros N. Teknos, Quintin Pan, Wendi Quinn O'Neill |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Laryngoscope investigative otolaryngology. 7(4) |
| ISSN: |
2378-8038 |
| Popis: |
The incidence of p16+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing. The notion that p16+ OPSCC has a propensity for atypical and disseminating metastasis has gained traction. We compared treatment failure patterns in p16+ and p16- OPSCC and evaluated survival impact.Retrospective analysis of patients with recurrent/metastatic OPSCC disease between 1/2009 and 12/2019.Thirty-eight p16+ and 36 p16- patients were identified. Three distinct failure patterns (distant vs. locoregional, atypical vs. typical, and disseminating vs. non-disseminating) were studied. No significant differences were found between p16+ and p16- patients. Multivariate analysis showed p16 status was an independent prognostic biomarker; p16+ patients have a favorable overall survival compared to p16- patients (HR 0.34, 95% CI 0.16-0.77;We challenge the view that p16+ OPSCC exhibits a distinctive treatment failure pattern and showed that p16 status impacts patient survival independent of disease progression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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