Potential roles of stem cell marker genes in axon regeneration

Autor: Yongcheol Cho, Jinyoung Lee
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Experimental & Molecular Medicine
ISSN: 2092-6413
1226-3613
Popis: Axon regeneration is orchestrated by many genes that are differentially expressed in response to injury. Through a comparative analysis of gene expression profiling, injury-responsive genes that are potential targets for understanding the mechanisms underlying regeneration have been revealed. As the efficiency of axon regeneration in both the peripheral and central nervous systems can be manipulated, we suggest that identifying regeneration-associated genes is a promising approach for developing therapeutic applications in vivo. Here, we review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.
Nerve cells: activating genetic switches to repair injury Understanding which genes are switched on/off in nerve cells in response to injury may help develop new treatments to repair nerves. Nerve cells can be cued to regenerate in both the central (brain and spinal cord) and peripheral nervous systems. Studying patterns of post-injury gene activation may allow therapeutic boosting of injury-responsive genes to cue nerve regrowth. Jinyoung Lee and Yongcheol Cho at Korea University, Seoul, South Korea have reviewed those genes identified as markers of stem cells (cells with high regenerative capacity) that are differentially regulated in nerve cells. They present several promising target genes for further study, noting that little is known of the mechanisms underlying regeneration or the interacting genetic pathways. These results point the way to identifying genetic targets to improve treatment for nerve damage.
Databáze: OpenAIRE
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