Stepwise increasing sequential offsets cannot be used to deliver high thermal intensities with little or no perception of pain
| Autor: | Christopher L. Asplund, Stuart W. G. Derbyshire, Victoria Jane En Long |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nociception medicine.medical_specialty Offset (computer science) Materials science Physiology media_common.quotation_subject Audiology 03 medical and health sciences Young Adult 0302 clinical medicine 030202 anesthesiology Heat stimulus Perception Thermal medicine Psychophysics Humans Thermosensing media_common Pain Measurement Pain experience Thermal perception General Neuroscience Female Analgesia 030217 neurology & neurosurgery Intensity (heat transfer) |
| Zdroj: | Journal of neurophysiology. 122(2) |
| ISSN: | 1522-1598 |
| Popis: | Offset analgesia (OA) is the disproportionate decrease in pain experience following a slight decrease in noxious heat stimulus intensity. We tested whether sequential offsets would allow noxious temperatures to be reached with little or no perception of pain. Forty-eight participants continuously rated their pain experience during trials containing trains of heat stimuli delivered by Peltier thermode. Stimuli were adjusted through either stepwise sequential increases of 2°C and decreases of 1°C or direct step increases of 1°C up to a maximum of 46°C. Step durations (1, 2, 3, or 6 s) varied by trial. Pain ratings generally followed presented temperature, regardless of step condition or duration. For 6-s steps, OA was observed after each decrease, but the overall pain trajectory was unchanged. We found no evidence that sequential offsets could allow for little pain perception during noxious temperature presentation. NEW & NOTEWORTHY Offset analgesia is the disproportionate decrease in pain experience following a slight decrease in noxious heat stimulus intensity. We tested whether sequential offsets would allow noxious temperatures to be reached with little or no perception of pain. We found little evidence of such overall analgesia. In contrast, we observed analgesic effects after each offset with long-duration stimuli, even with relatively low-temperature noxious stimuli. |
| Databáze: | OpenAIRE |
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