Attempted Prevention of Blast Crisis in Chronic Myeloid Leukemia by the use of Pulsed Doses of Cytarabine and Lomustine A Cancer and Leukemia Group B Study
| Autor: | Kurt Brunner, Farid I. Haurani, Keith Dear, Richard T. Silver, James F. Holland, Arthur Karanas, Marise Weil |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Drug Oncology Cancer Research medicine.medical_specialty Time Factors media_common.quotation_subject Pharmacology Lomustine Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Busulfan media_common business.industry Remission Induction Cytarabine Myeloid leukemia Cancer Hematology Middle Aged medicine.disease Discontinuation Leukemia Female Blast Crisis business Follow-Up Studies medicine.drug |
| Zdroj: | Leukemia & Lymphoma. 7:63-68 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199209053603 |
| Popis: | An attempt to prevent the blast crisis in chronic myeloid leukemia by the use of pulsed doses of (cytarabine cytosine arabinoside) and lomustine was attempted as a cooperative group study by Cancer and Leukemia Group B. The basis for this study was to delay the development of blast crisis by pulsing dose of drugs known to be effective against emerging "blast" cells. The experimental arm which consisted of cytarabine and lomustine did not produce overall results superior to conventional treatment with busulfan. This was related to the non-hematologic effects of the combination which produced significant gastrointestinal toxicity leading to relatively early discontinuation of the combination. Nevertheless, the trial design allowed relatively prompt discontinuation of experimental arm and cross-over to conventional treatment with either hydrea or busulfan. No evidence existed that the use of new drug combinations in CML prejudiced the patient's chance to response to conventional chemotherapy. Thus, a role model for future trials in this disease was developed. With the development of the interferons and other experimental forms of therapy this conceptual development may be of significance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|