Bending Resistance at Hip and Fractures Risk in Postmenopausal Women Independent of Bone Mineral Density
| Autor: | Elisa Mazza, Arturo Pujia, Tiziana Montalcini, Roberta Pujia, Nadia Geirola, Carmine Gazzaruso, Stefano Romeo, Samantha Maurotti, Yvelise Ferro |
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| Rok vydání: | 2021 |
| Předmět: |
Fracture risk
Male Endocrinology Diabetes and Metabolism Osteoporosis Hip structure Dentistry Absorptiometry Photon Bone Density medicine Humans Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Osteoporosis Postmenopausal Bone mineral Postmenopausal women business.industry Femur Neck Hip Fractures Odds ratio medicine.disease Postmenopause Cross-Sectional Studies Axial load Female business Bone mass |
| Zdroj: | Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry. 25(2) |
| ISSN: | 1094-6950 |
| Popis: | Several studies suggest that aging loss of bone mass is not necessarily associated with reduced mechanical proprieties as bending resistance. Since postmenopausal women with fracture and without osteoporosis might have an impairment in the bending mechanisms at hip, our aim was to assess if women with and without fractures differ in the femoral parameters of resistance to bending, independent of the bone loss. In this cross-sectional study we enrolled 192 postmenopausal women who underwent X-ray absorptiometry scan to measure bone mineral density as well as cross-sectional geometry parameters at the hip (Hip structure analysis). Among women with osteoporosis, a higher odds ratio for fracture was found in the first tertile of NN-Dmax, a parameter linked to the resistance to bending forces in a cross-section (tertile I, OR = 6.7, p = 0.03; CI 1.19–38.01; reference tertile III). We also found a significantly higher risk for major fracture in the first tertile of NN-Dmax (tertile I, OR = 6.0, p = 0.02; CI 1.26−28.4; reference tertile III). Among women without osteoporosis, a significantly higher odds ratio for fracture was found in the first tertile of IT-CSA, a parameter of resistance to axial load (tertile I, OR = 7.2, p = 0.002; CI 2.04–25.9; reference tertile III). We also found a significantly higher risk for major fracture in the first tertile of IT-CSA (OR = 18.4, p = 0.001; CI 1.52−221.8; tertile III reference). We demonstrate that some hip structural parameters are independently associated to the fracture risk in postmenopausal women. |
| Databáze: | OpenAIRE |
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