Cataloguing the phosphorylation sites of tristetraprolin (TTP): Functional implications for inflammatory diseases
| Autor: | Trisha Al-mazi, Maria C. Rezcallah, Alaina J. Ammit |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Phosphatase Tristetraprolin Inflammation Biology Serine Mice 03 medical and health sciences 0302 clinical medicine Protein Domains hemic and lymphatic diseases Gene expression medicine Animals Humans heterocyclic compounds Phosphorylation neoplasms Calcium signaling Kinase Cell Biology respiratory system Cell biology 030104 developmental biology 030220 oncology & carcinogenesis medicine.symptom therapeutics |
| Zdroj: | Cellular Signalling. 78:109868 |
| ISSN: | 0898-6568 |
| DOI: | 10.1016/j.cellsig.2020.109868 |
| Popis: | Tristetraprolin (TTP) is a destabilizing mRNA binding protein known to regulate gene expression of a wide variety of targets, including those that control inflammation. TTP expression, regulation and function is controlled by phosphorylation. While the importance of key serine (S) sites (S52 and S178 in mice and S186 in humans) has been recognized, other sites on the hyperphosphorylated TTP protein have more recently emerged as playing an important role in regulating cellular signalling and downstream functions of TTP. In order to propel investigation of TTP and fully exploit its potential as a drug target in inflammatory disease, this review will catalogue TTP phosphorylation sites in both the murine and human TTP protein, the known and unknown roles and functions of these sites, the kinases and phosphatases that act upon TTP and overview methodological approaches to increase our knowledge of this important protein regulated by phosphorylation. |
| Databáze: | OpenAIRE |
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