Passive narcosis for anesthesia induction in cotton rats (Sigmodon hispidus)
| Autor: | Lydia Anderson, Patricia A. Jorquera, C. M. Williams, Ralph A. Tripp, Jarod M Hanson |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Intoxicative inhalant Isoflurane General Veterinary business.industry Sigmodon hispidus 03 medical and health sciences 030104 developmental biology Human disease Infectious disease (medical specialty) Anesthesia Anesthetics Inhalation Anesthetic Increased stress Animals Home cage Medicine Female Animal Science and Zoology Sigmodontinae Anesthesia induction business medicine.drug |
| Zdroj: | Lab Animal. 45:333-337 |
| ISSN: | 1548-4475 0093-7355 |
| Popis: | Cotton rats (Sigmodon hispidus) are widely used as animal models for infectious disease and immunological research. They emulate many aspects of human disease pathogenesis, and the introduction of cotton rat-specific immunological reagents, cell lines and sequencing of relevant genes have all helped to increase the popularity of this disease model. However, the use of cotton rats is problematic owing to their propensity for aggressive responses when handled, which can lead to escape, increased stress to the animals, and bites to staff. When cotton rats are co-housed, which is recommended under current social housing guidelines, these risks are increased. Here, we describe a method of isoflurane anesthesia induction in the home cage that reduces the risk of animal escape, minimizes stress during induction, and provides additional safety for staff. The method uses inexpensive materials that are widely available and can be easily disinfected. Our method also eliminates the need for expensive and cumbersome machines traditionally used with anesthetic chambers, and uses a minimal amount of inhalant anesthetic, saving resources and protecting staff from inhalation of leaked gas. |
| Databáze: | OpenAIRE |
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