ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege
| Autor: | Kenneth M. Murphy, Marie Claude Hofmann, Chris E. Hostetler, Paul S. Cooke, Carla M.K. Morrow, Rex A. Hess, Michael D. Griswold |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Cell type medicine.medical_specialty endocrine system Biology Models Biological General Biochemistry Genetics and Molecular Biology Article Tight Junctions Andrology Mice History and Philosophy of Science Immune privilege Internal medicine Testis medicine Animals Spermatogenesis Blood-Testis Barrier Blood–testis barrier Mice Knockout Tight junction General Neuroscience Sertoli cell Immunity Innate Transplantation DNA-Binding Proteins Endocrinology medicine.anatomical_structure Stem cell Transcription Factors |
| Zdroj: | Annals of the New York Academy of Sciences. 1120 |
| ISSN: | 0077-8923 |
| Popis: | The transcription factor Ets-variant gene 5 (ETV5) is essential for spermatogonial stem cell (SSC) self-renewal, as the targeted deletion of the Etv5 gene in mice (Etv5(-/-)) results in only the first wave of spermatogenesis. Reciprocal transplants of neonatal germ cells from wild-type (WT) and Etv5(-/-) testes were performed to determine the role of ETV5 in Sertoli cells and germ cells. ETV5 appears to be needed in both cell types for normal spermatogenesis. In addition, Etv5(-/-) recipients displayed increased interstitial inflammation and tubular involution after transplantation. Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse. |
| Databáze: | OpenAIRE |
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