Single nucleotide polymorphisms in nucleotide excision repair genes, cancer treatment, and head and neck cancer survival
| Autor: | Andrew F. Olshan, Annah Wyss, Mark C. Weissler, Jeannette T. Bensen, Christy L. Avery, Jill S. Barnholtz-Sloan, William K. Funkhouser, Amy H. Herring |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology DNA Repair Genotype DNA repair medicine.medical_treatment Black People Single-nucleotide polymorphism Polymorphism Single Nucleotide White People Article Young Adult chemistry.chemical_compound Internal medicine North Carolina medicine Humans Gene Aged Proportional Hazards Models Aged 80 and over Chemotherapy Hematology business.industry Head and neck cancer Middle Aged Prognosis medicine.disease Survival Rate Oncology chemistry Head and Neck Neoplasms Case-Control Studies Cancer research Female business DNA Nucleotide excision repair |
| DOI: | 10.17615/j2ft-vy03 |
| Popis: | Head and neck cancers (HNC) are commonly treated with radiation and platinum-based chemotherapy, which produce bulky DNA adducts to eradicate cancerous cells. Because nucleotide excision repair (NER) enzymes remove adducts, variants in NER genes may be associated with survival among HNC cases both independently and jointly with treatment.Cox proportional hazards models were used to estimate race-stratified (White, African American) hazard ratios (HRs) and 95 % confidence intervals for overall (OS) and disease-specific (DS) survival based on treatment (combinations of surgery, radiation, and chemotherapy) and 84 single nucleotide polymorphisms (SNPs) in 15 NER genes among 1,227 HNC cases from the Carolina Head and Neck Cancer Epidemiology Study.None of the NER variants evaluated were associated with survival at a Bonferroni-corrected alpha of 0.0006. However, rs3136038 [OS HR = 0.79 (0.65, 0.97), DS HR = 0.69 (0.51, 0.93)] and rs3136130 [OS HR = 0.78 (0.64, 0.96), DS HR = 0.68 (0.50, 0.92)] of ERCC4 and rs50871 [OS HR = 0.80 (0.64, 1.00), DS HR = 0.67 (0.48, 0.92)] of ERCC2 among Whites, and rs2607755 [OS HR = 0.62 (0.45, 0.86), DS HR = 0.51 (0.30, 0.86)] of XPC among African Americans were suggestively associated with survival at an uncorrected alpha of 0.05. Three SNP-treatment joint effects showed possible departures from additivity among Whites.Our study, a large and extensive evaluation of SNPs in NER genes and HNC survival, identified mostly null associations, though a few variants were suggestively associated with survival and potentially interacted additively with treatment. |
| Databáze: | OpenAIRE |
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