Isolation and characterization of new 18-membered macrolides FD-891 and FD-892

Autor:	Tadayasu Okazaki, Noriyoshi Sakai, Kazutoshi Mizoue, Mitsuko Seki-Asano, Michio Yamagishi, Kazunori Hanada
Rok vydání:	1994
Předmět:	Adenosine Triphosphatases Pharmacology biology Streptomycetaceae biology.organism_classification Streptomyces In vitro Anti-Bacterial Agents Mice Biochemistry Cell culture Fermentation Drug Discovery medicine Animals Humans Doxorubicin Macrolides Actinomycetales Bacteria medicine.drug
Zdroj:	The Journal of Antibiotics. 47:1226-1233
ISSN:	1881-1469 0021-8820
Popis:	New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture Japan. They induce morphological changes of HL-60 cells at low concentration below IC50s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 approximately 7 times stronger activity than doxorubicin whereas FD-892 was 20 approximately 100 fold weaker than FD-891 and doxorubicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6fbcd4132ac033239f3f1f7995e481 https://doi.org/10.7164/antibiotics.47.1226 Zobrazit plný text záznamu