Bone Formation and Adaptive Morphology of the Anterior Tibial Muscle in 3-mm Daily Lengthening Using High-Fractional Automated Distraction and Osteosynthesis with the Ilizarov Apparatus Combined with Intramedullary Hydroxyapatite-Coated Wire
| Autor: | D. A. Popkov, G. N Filimonova, N. A. Kononovich, Arnold Popkov, E. N. Gorbach |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Ilizarov Technique
Article Subject medicine.medical_treatment lcsh:Medicine Osteotomy General Biochemistry Genetics and Molecular Biology law.invention Intramedullary rod Fracture Fixation Internal 03 medical and health sciences Dogs 0302 clinical medicine Coated Materials Biocompatible Osteogenesis law Fracture fixation medicine Animals Humans 030212 general & internal medicine Tibia Muscle Skeletal Titanium Orthodontics 030222 orthopedics Osteosynthesis General Immunology and Microbiology business.industry lcsh:R General Medicine Ilizarov apparatus Fracture Fixation Intramedullary Disease Models Animal Diaphysis Durapatite medicine.anatomical_structure business Research Article |
| Zdroj: | BioMed Research International, Vol 2019 (2019) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2019/3241263 |
| Popis: | Purpose. We studied osteogenesis and morphofunctional features of the anterior tibial muscle using 3-mm high-frequency automated lengthening with the Ilizarov apparatus alone and in combination with intramedullary nailing. Material and Methods. Tibia was lengthened with a round-the-clock automated distractor at a 3-mm daily rate for 10 days in 16 mongrel dogs. In group 1 (n = 8), a 1.8-mm intramedullary titanium wire coated with hydroxyapatite was introduced into the tibial canal followed by Ilizarov frame mounting and transverse osteotomy of the diaphysis. Distraction mode was 0.025 mm x 120 increments a day. In group 2 (n = 8), distraction mode was the same but nailing was not used. Bone formation and the anterior tibial muscle were studied at two time points: (1) upon distraction completion; (2) three months after the apparatus removal. Bone formation was studied radiographically. Muscle preparations were examined histologically and stereomicroscopically. Results. There was a threefold reduction in the distraction time in both groups. Consolidation took 13.83±4.02 days in group 1 and 33.7±2.4 days in group 2. Muscle macropreparations of the experimental limb in group 1 at study time points did not show significant differences from intact tissues. Muscle histostructure in both groups was characterized by activation of angiogenesis and myohistogenesis, but the volumetric density of microvessels in the lengthening phase was three times higher in group 1. Conclusion. Combined technology significantly reduces the total lengthening procedure and does not compromise limb functions. Intramedullary HA-coated wires promote faster bone formation. The muscle was able to exhibit structural adaptation and plasticity of a restitution type. |
| Databáze: | OpenAIRE |
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