Interaction between behavioral inhibition and neural alcohol cue-reactivity in ADHD and alcohol use disorder

Autor:	Oliver Hennig, Derik Hermann, G Sharafi, Barbara Alm, J Seidt, Sabine Vollstädt-Klein, Esther Sobanski, R Nuriyeva, Mathias Luderer, A Lee, A Strosche, Falk Kiefer, Wolfgang H. Sommer, Sarah Gerhardt
Rok vydání:	2020
Předmět:	Adult Male Attention-deficit / hyperactivity disorder Impulsivity Functional magnetic resonance imaging Population Comorbidity Alcohol use disorder Cue-reactivity behavioral disciplines and activities Young Adult Reward Conditioning Psychological Interference inhibition mental disorders Humans Medicine Attention deficit hyperactivity disorder Inhibitory control education Original Investigation Pharmacology education.field_of_study medicine.diagnostic_test business.industry Brain Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Alcoholism Inhibition Psychological Attention Deficit Disorder with Hyperactivity Cue reactivity Reward system Female Cues Nerve Net medicine.symptom business Photic Stimulation Clinical psychology
Zdroj:	Psychopharmacology
ISSN:	1432-2072 0033-3158
DOI:	10.1007/s00213-020-05492-1
Popis:	Rationale Compared to the general population, adult Attention-Deficit / Hyperactivity Disorder (ADHD) is more prevalent in patients with Alcohol Use Disorder (AUD). Impaired behavioral inhibition is a common characteristic in both ADHD and AUD. Relapse risk is increased in patients with AUD and comorbid, untreated ADHD and in AUD patients with increased neural cue-reactivity. Objectives In this study, we examined the interaction between neural correlates of behavioral inhibition and alcohol cue-reactivity with a hybrid imaging task. Methods Out of 69 adult study participants, we included n = 49 in our final analyses: Individuals had a diagnosis of either AUD (n = 13), ADHD (n = 14) or both (n = 5), or were healthy controls (HC; n = 17). The functional magnetic resonance imaging paradigm aimed to examine the combined effects of both an interference-inhibition task (“Simon-task”) and an alcohol cue-reactivity task. Instead of segregating by diagnostic group, we pursued a dimensional approach in which we compared measures of AUD and ADHD severity, as well as the interaction of both, using multiple regression analyses. Results The four groups did not differ on the behavioral level on either the inhibition task or the alcohol cue-reactivity task. However, brain activation in frontal control and reward-related regions during completion of the combined tasks were related to ADHD and AUD severity (symptom load). During presentation of both alcohol cues and the inhibition task, participants with higher AUD and ADHD symptom load exhibited greater BOLD (blood oxygen level dependent) responses in subcortical reward-related regions. Conclusions Our findings support the hypothesis that ADHD additionally diminishes inhibition ability in individuals with AUD. This may increase relapse risk when confronted with alcohol cues. Further, it is crucial for patients with comorbid AUD and ADHD to take into account not only reduced cognitive control over behavioral inhibition but also simultaneously heightened alcohol cue-reactivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5bdaba79877edaeda2e31128f3a2f1 https://doi.org/10.1007/s00213-020-05492-1 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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