Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus
| Autor: | Ann V. Griffith, Sergio Cepeda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Stromal cell T-Lymphocytes Population Thymus Gland Biochemistry Article Mice 03 medical and health sciences Endocrinology Atrophy Immune system Genetics Animals Humans Medicine education Molecular Biology Thymic atrophy education.field_of_study business.industry Extramural Cell Biology T lymphocyte medicine.disease 030104 developmental biology Immunology Stromal Cells business |
| Zdroj: | Experimental Gerontology. 105:113-117 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2017.12.022 |
| Popis: | Atrophy of the thymus, the primary site of T lymphocyte generation, is a hallmark of the aging immune system. Age-associated thymic atrophy results in diminished output of new, naïve T cells, with immune sequelae that include diminished responses to novel pathogenic challenge and vaccines, as well as diminished tumor surveillance. Although a variety of stimuli are known to regulate transient thymic atrophy, mechanisms governing progressive age-associated atrophy have been difficult to resolve. This has been due in part to the fact that one of the primary targets of age-associated thymic atrophy is a relatively rare population, thymic stromal cells. This review focuses on changes in thymic stromal cells during aging and on the contributions of periodic, stochastic, and progressive causes of thymic atrophy. |
| Databáze: | OpenAIRE |
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