White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
| Autor: | Nicolas Bouladoux, Allyson L. Byrd, Nicholas Collins, Amiran Dzutsev, Yasmine Belkaid, Arielle Glatman Zaretsky, Igor E. Brodsky, Margery G. Smelkinson, Denise Morais da Fonseca, Oliver J. Harrison, James B. Bliska, Jason M. Brenchley, Jahangheer S. Shaik, Vinicius Andrade-Oliveira, Seong-Ji Han, Samira Tamoutounour |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Lymphocyte Transgene Adipose Tissue White Immunology Adipose tissue Gene Expression Yersinia pseudotuberculosis Infections Mice Transgenic White adipose tissue Biology CD8-Positive T-Lymphocytes 03 medical and health sciences Interferon-gamma Mice Bacterial Proteins Genes Reporter Gene expression medicine Immunology and Allergy Animals Pathogen Effector Tumor Necrosis Factor-alpha Interleukin-17 Lipid metabolism Lipid Metabolism Survival Analysis Cell biology Mice Inbred C57BL Luminescent Proteins 030104 developmental biology Infectious Diseases medicine.anatomical_structure Yersinia pseudotuberculosis Tissue Transplantation Interleukin-5 Immunologic Memory Toxoplasma Toxoplasmosis |
| Zdroj: | Immunity. 47(6) |
| ISSN: | 1097-4180 |
| Popis: | White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we have shown that at steady state, white adipose tissue contained abundant memory lymphocyte populations. After infection, white adipose tissue accumulated large numbers of pathogen-specific memory T cells, including tissue-resident cells. Memory T cells in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previously infected mice was sufficient to protect uninfected mice from lethal pathogen challenge. Induction of recall responses within white adipose tissue was associated with the collapse of lipid metabolism in favor of antimicrobial responses. Our results suggest that white adipose tissue represents a memory T cell reservoir that provides potent and rapid effector memory responses, positioning this compartment as a potential major contributor to immunological memory. |
| Databáze: | OpenAIRE |
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