The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling
| Autor: | Jeffrey Downey, Leandro Silva da Costa, Armin Farahvash, Stephen E. Girardin, Aaron Trotman-Grant, Ryan G. Gaudet, Maziar Divangahi, Leticia A.M. Carneiro, Damien Arnoult, Farshad C. Azimi, Jeffrey E. Lee, Charles C. Y. Lau, Raphael Molinaro, Nichole K. Escalante, Dave Prescott, Scott D. Gray-Owen, Elise Sofie Hovingh, J J Chen, Ahmed Outlioua, Dana J. Philpott, Jessica Tsalikis, Rob van Dalen, Mena Abdel-Nour |
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| Přispěvatelé: | McGill University Health Center [Montreal] (MUHC), INSERM U1197 |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Listeria Eukaryotic Initiation Factor-2 Nod2 Signaling Adaptor Protein [SDV.BC]Life Sciences [q-bio]/Cellular Biology Protein Serine-Threonine Kinases Cell Line Mice 03 medical and health sciences Cytosol 0302 clinical medicine Salmonella Nod1 Signaling Adaptor Protein Eukaryotic initiation factor NOD1 Animals Humans Endoplasmic Reticulum Chaperone BiP Heat-Shock Proteins ComputingMilieux_MISCELLANEOUS Adaptor Proteins Signal Transducing Multidisciplinary Innate immune system Chemistry Endoplasmic reticulum ATF4 Membrane Proteins Fibroblasts Activating Transcription Factor 4 Immunity Innate Mice Mutant Strains Cell biology Adaptor Proteins Vesicular Transport 030104 developmental biology TRIF Myeloid Differentiation Factor 88 Salmonella Infections Unfolded Protein Response Unfolded protein response Shigella Signal transduction 030217 neurology & neurosurgery Molecular Chaperones Signal Transduction |
| Zdroj: | Science Science, American Association for the Advancement of Science, 2019, 365 (6448), pp.eaaw4144. ⟨10.1126/science.aaw4144⟩ |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aaw4144 |
| Popis: | Linking protein misfolding and innate immunity Multiple innate immune sensors undergo rapid assembly into large complexes known as signalosomes. This is an essential step during cellular responses to microbes and danger signals. How this process is regulated to avoid accumulation of potentially toxic protein aggregates remains poorly understood. Abdel-Nour et al. identified a pathway, dependent on heme-regulated inhibitor, eukaryotic initiation factor 2α, activating transcription factor 4, and heat shock protein B8, which controls the folding and scaffolding of innate immune sensors, allowing optimal proinflammatory signaling (see the Perspective by Pierre). The pathway appears to mirror the endoplasmic reticulum unfolded protein response (UPR), and so was named the cytosolic UPR (cUPR). The cUPR may represent a general mechanism to control protein misfolding in cells. Science , this issue p. eaaw4144 ; see also p. 28 |
| Databáze: | OpenAIRE |
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