Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico

Autor: Yolanda Jaramillo-Rodríguez, Carmen Adalid-Sáinz, Rodrigo Barquera, Néstor Escareño-Montiel, Mario J. Sandoval-Sandoval, Joaquín Zúñiga, Alicia Bravo-Acevedo, Abraham Lona-Sánchez, Julio Granados, Julio César Martínez-Álvarez, Antonio Salgado-Adame, Vicencio Juárez-Barreto, Benjamín Gómez-Navarro, Liliana González-Medina, Edmond J. Yunis, Carolina Bekker-Méndez, Jorge Arturo Pantoja-Torres, Araceli Escobedo-Ruíz, Isis Goné-Vázquez, Hanna Pacheco-Ubaldo, Esteban Arrieta-Bolaños, Diana Iraíz Hernández-Zaragoza, María Guadalupe de Jesús Sánchez-Fernández, Federico Juárez-de la Cruz, María Araceli Arrazola-García, Marisela del Rocío González-Martínez, Héctor Delgado-Aguirre, Stephen Clayton, Gamaliel Benítez-Arvizu
Rok vydání: 2020
Předmět:
Zdroj: Human Immunology. 81:519-521
ISSN: 0198-8859
DOI: 10.1016/j.humimm.2019.05.016
Popis: We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 95 Mexicans from the state of Aguascalientes to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes in the state of Aguascalientes include four Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Aguascalientes are Native American (54.53 ± 3.22% by ML; 44.21% of Native American haplotypes) and European (44.34 ± 0.45% by ML; 40.53% of European haplotypes), and a relatively low African genetic component (1.13 ± 2.33% by ML; 5.26% of African haplotypes).
Databáze: OpenAIRE
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