Metabolic syndrome positively correlates with the risks of atherosclerosis and diabetes in a Chinese population
| Autor: | Sung-Sheng Tsai, Szu-Tah Chen, Pao-Hsien Chu, Yu-Sheng Lin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Taiwan 030209 endocrinology & metabolism Pulse Wave Analysis 030204 cardiovascular system & hematology Risk Assessment Severity of Illness Index Young Adult 03 medical and health sciences Vascular Stiffness 0302 clinical medicine Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Internal Medicine medicine Humans Ankle Brachial Index Pulse wave velocity health care economics and organizations Aged Aged 80 and over Metabolic Syndrome Receiver operating characteristic business.industry Middle Aged Atherosclerosis medicine.disease Obesity Cross-Sectional Studies Postprandial ROC Curve Area Under Curve Arterial stiffness Cardiology Female Waist Circumference Metabolic syndrome business |
| Zdroj: | European Journal of Internal Medicine. 54:40-45 |
| ISSN: | 0953-6205 |
| DOI: | 10.1016/j.ejim.2018.04.009 |
| Popis: | Published studies seldom tested the weight of different waist circumference (WC) cut-off values for the diagnosis of metabolic syndrome (MetS) in predicting clinical outcomes, including cardiovascular disease and diabetes.This is a Chinese population-based cross-sectional study screening subjects from a Health Examination Program since 1999 to 2015. The MetS identification and scores were determined either according to the Adult Treatment Panel III/American Heart Association/National Heart, Lung, and Blood Institute (ATP III/AHA/NHLBI)- or Asian-WC cut-off points. The developments of a higher brachial-ankle pulse wave velocity (baPWV), defined as ≥1400 cm/s, and diabetic-level hyperglycemia, defined as a high fasting glucose level ≥6.99 mmol/L or postprandial glucose level ≧11.10 mmol/L, were surveyed by comparing the areas under receiver operating characteristic curves (AUC-ROC) for both MetS scores.According to the ATP III/AHA/NHLBI- vs Asian-MetS criteria, 6633 vs 9133 (24.8% vs 34.2%, p 0.001) subjects were diagnosed as the MetS among 26,735 study subjects with a mean age of 55 ± 12 years. The stepwise increases in baPWV and prevalence of diabetic-level hyperglycemia were associated with both MetS scores after adjusting for age and sex. Both MetS scores yielded similar results for correlation with a higher baPWV (AUC-ROC = 0.685 for ATP III/AHA/HLBI- vs 0.680 for Asian-MetS, p = 0.271) and diabetic-level hyperglycemia (AUC-ROC = 0.791 for ATP III/AHA/HLBI- vs 0.784 for Asian-MetS, p = 0.546).In a stepwise manner, both ATP III/AHA/NHLBI- or Asian-MetS scores were strong risk factors for arterial stiffness and diabetes. Through a novel and holistic approach, the performance of the ATP III/AHA/NHLBI-MetS score for the risks of arterial stiffness and diabetes was comparable to the Asian-MetS score among a Chinese population. |
| Databáze: | OpenAIRE |
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