Primary hepatic carcinoid tumor
| Autor: | Tsutomu Tomioka, Takayuki Asakawa, Takashi Kanematsu, Tsukasa Tsunoda, Takashi Yamaguchi, Kuniko Abe |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Pathology Carcinoid tumors medicine.medical_treatment Antineoplastic Agents Autopsy Carcinoid Tumor Fatal Outcome Satellite Nodule Surgical oncology Internal medicine medicine Hepatectomy Humans Neoplasm Invasiveness Chemoembolization Therapeutic Transcatheter arterial chemoembolization biology business.industry Liver Neoplasms Gastroenterology Chromogranin A Middle Aged Hepatology medicine.disease Injections Intra-Arterial biology.protein Female business Follow-Up Studies |
| Zdroj: | Journal of Gastroenterology. 34:123-127 |
| ISSN: | 1435-5922 0944-1174 |
| DOI: | 10.1007/s005350050227 |
| Popis: | A primary hepatic carcinoid tumor arising in a 49-year-old woman is reported. The patient was admitted with multiple hepatic tumors and treated by a left lobectomy and cholecystectomy. Cut sections of the specimen revealed a solid and necrotic mass, measuring 10 x 12 x 13 cm, with multiple small satellite nodules. Histologically, the tumor cells had small oval-shaped nuclei and presented with a trabecular arrangement and rosette-like formation. Both Grimelius and Fontana-Mason stainings were positive. The tumor cells were positive for chromogranin A and negative for other antigens. Ultrastructural studies of the tumor cells revealed duct-like formation with microvilli and a cluster of dense small immature neurosecretory granules in the cytoplasm. These findings were consistent with those of carcinoid tumors. Postoperatively, the patient was treated with repeated transcatheter arterial chemoembolization for any remnant tumors. However, she died of the disease 5 years after the initial surgery. The autopsy findings suggested the primary site to be the liver. |
| Databáze: | OpenAIRE |
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