Correction: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders
| Autor: | Henry Völzke, Ben J. Harrison, Bonnie Klimes-Dougan, Bernhard T. Baune, Mon-Ju Wu, Jair C. Soares, Yuri Milaneschi, Norbert Hosten, Meng Li, Maike Richter, Janik Goltermann, Axel Krug, Benson Mwangi, Giovana Zunta-Soares, Martin Walter, Katharina Wittfeld, Thomas Frodl, Ramona Leenings, Christopher G. Davey, Lyubomir I. Aftanas, Ian B. Hickie, Udo Dannlowski, Anbupalam Thalamuthu, Nils Opel, Ilya M. Veer, Angela Carballedo, Mathew A. Harris, Marco Hermesdorf, Georg Woditsch, Elena Pozzi, Lianne Schmaal, Kang Sim, Heather C. Whalley, Paul M. Thompson, Laura Nawijn, Liesbeth Reneman, Claas Flint, Dominik Grotegerd, Bryon A. Mueller, Klaus Berger, Kathryn R. Cullen, Hans J. Grabe, Elena Filimonova, Sandra Van der Auwera, Matthew D. Sacchet, Tim Hahn, Frank P. MacMaster, Sean N. Hatton, Neda Jahanshad, André Aleman, Dick J. Veltman, Igor Nenadic, Evgeniy A. Osipov, Tilo Kircher, Henrik Walter, Dan J. Stein, Andrew M. McIntosh, Ian H. Gotlib, Nynke A. Groenewold, Philipp G. Sämann, Brenda W.J.H. Penninx, Ivan V. Brak, Anouk Schrantee, Jim Lagopoulos |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
business.industry Physiology Genetic data medicine.disease Obesity Left fusiform gyrus 03 medical and health sciences Cellular and Molecular Neuroscience Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine medicine Major depressive disorder Polygenic risk score ddc:610 Genetic risk business Molecular Biology Pathological 030217 neurology & neurosurgery |
| Zdroj: | Molecular psychiatry 26(12), 7854 (2021). doi:10.1038/s41380-021-01191-1 |
| DOI: | 10.1038/s41380-021-01191-1 |
| Popis: | Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = −0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions. |
| Databáze: | OpenAIRE |
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