Trophic action of epidermal growth factor on human duodenal mucosa cultured in vitro
| Autor: | E E Wheeler, D N Challacombe |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Duodenum Crypt Mitosis Stimulation Biology digestive system Intestinal mucosa Epidermal growth factor Internal medicine medicine Humans Intestinal Mucosa Cells Cultured Microdissection Aged Aged 80 and over Epidermal Growth Factor integumentary system Gastroenterology Molecular biology In vitro medicine.anatomical_structure Endocrinology Female Research Article Explant culture |
| Zdroj: | Gut. 32:991-993 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.32.9.991 |
| Popis: | The action of epidermal growth factor on the human duodenal mucosa has been studied by estimating the crypt cell production rate in cultured explants, using a stathmokinetic technique with crypt microdissection. The addition of epidermal growth factor (400 ng/ml) to paired explants from five patients caused an almost fivefold increase in the crypt cell production rate, showing that epidermal growth factor has a trophic action on the human duodenal mucosa in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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