First insights into clinical and resistance features of infections by Klebsiella pneumoniae among oncological patients from a referral center in amazon region, Brazil

Autor: Luana Nepomuceno Gondim Costa Lima, Anderson Lineu Siqueira dos Santos, Marcos Vinícios Hino de Melo, Danielle Murici Brasiliense, Pabllo Antonny Silva dos Santos, Daniele Melo Sardinha, Karla Valéria Batista Lima, Tatyellen Natasha da Costa Oliveira, Yan Corrêa Rodrigues
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Repositório Digital do Instituto Evandro Chagas (Patuá)
Instituto Evandro Chagas (IEC)
instacron:IEC
Infectious Disease Reports
Infectious Disease Reports, Vol 12, Iss 21, Pp 110-120 (2020)
Popis: This research was supported by funding from the Funda??o de Amparo ? Pesquisa do Par?/Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (FAPESPA/CAPES) [Cooperation grant N?017/2014], Programa Institucional de Bolsas de Inicia??o Cient?fica/Funda??o Amaz?nia Paraense de Amparo ? Pesquisa/Universidade do Estado do Par? (FAPESPA/UEPA) [Cooperation grant N?001/2017/PPGBPA], Funda??o de Amparo ? Pesquisa do Par?/Universidade do Estado do Par? (FAPESPA/UEPA) [Cooperation grant N?004/2019] and the Instituto Evandro Chagas/Minist?rio da Sa?de/Secretaria de Vigil?ncia em Sa?de (IEC/MS/SVS) State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de P?s- Gradua??o em Epidemiologia e Vigil?ncia em Sa?de. Ananindeua, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. State University of Par?. Center of Biological and Health Sciences. Parasite Biology in the Amazon Region . Bel?m, PA, Brasil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Abstract: Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Par?, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Par?, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region.
Databáze: OpenAIRE
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