Development and validation of a method to record electrophysiological responses in direct acoustic cochlear implant subjects

Autor: Michael Hofmann, Jan Wouters, Nicolas Verhaert, Robin Gransier, Hanne Deprez
Rok vydání: 2018
Předmět:
Auditory brainstem response (ABR)
medicine.medical_specialty
Intraoperative Neurophysiological Monitoring
Hearing loss
Acoustic hearing implant
Audiology
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Prosthesis Fitting
Cadaver
Evoked Potentials
Auditory
Brain Stem
medicine
Humans
Inner ear
Hearing Loss
030223 otorhinolaryngology
Aged
Artifact (error)
Direct acoustic cochlear implant
business.industry
Reproducibility of Results
Auditory steady-state response (ASSR)
Intra-operative objective measures
Middle Aged
Radio frequency (RF) artifact modeling
Cochlear Implantation
Electric Stimulation
Sensory Systems
Electrophysiology
Cochlear Implants
Persons With Hearing Impairments
medicine.anatomical_structure
Acoustic Stimulation
Auditory Perception
Feasibility Studies
medicine.symptom
Artifacts
business
Auditory fatigue
030217 neurology & neurosurgery
Brain Stem
Zdroj: Hearing Research. 370:217-231
ISSN: 0378-5955
Popis: Acoustic hearing implants, such as direct acoustic cochlear implants (DACIs), can be used to treat profound mixed hearing loss. Electrophysiological responses in DACI subjects are of interest to confirm auditory processing intra-operatively, and to assist DACI fitting postoperatively. We present two related studies, focusing on DACI artifacts and electrophysiological measurements in DACI subjects, respectively. In the first study we aimed to characterize DACI artifacts, to study the feasibility of measuring frequency-specific electrophysiological responses in DACI subjects. Measurements of DACI artifacts were collected in a cadaveric head to disentangle possible DACI artifact sources and compared to a constructed DACI artifact template. It is shown that for moderate stimulation levels, DACI artifacts are mainly dominated by the artifact from the radio frequency (RF) communication signal, that can be modeled if the RF encoding protocol is known. In a second study, the feasibility of measuring intra-operative responses, without applying the RF artifact models, in DACI subjects is investigated. Auditory steady-state and brainstem responses were measured intra-operatively in three DACI subjects, immediately after implantation, to confirm proper DACI functioning and coupling to the inner ear. Intra-operative responses could be measured in two of the three tested subjects. Absence of intra-operative responses in the third subject can possibly be explained by the hearing loss, attenuation of intra-operative responses, the difference between electrophysiological and behavioral threshold, and a temporary threshold shift due to the DACI surgery. In conclusion, RF artifacts can be modeled, such that electrophysiological responses to frequency-specific stimuli could possibly be measured in DACI subjects, and intra-operative responses in DACI subjects can be obtained. ispartof: HEARING RESEARCH vol:370 pages:217-231 ispartof: location:Netherlands status: published
Databáze: OpenAIRE
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