Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors
| Autor: | O. L. Francone, C. J. Fielding |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Very low-density lipoprotein food.ingredient Apolipoprotein B Sterol O-acyltransferase Cholesterol 7 alpha-hydroxylase Lecithin chemistry.chemical_compound food Internal medicine medicine Humans Electrophoresis Gel Two-Dimensional Cells Cultured biology Cholesterol business.industry Reverse cholesterol transport Biological Transport Molecular Weight Endocrinology chemistry biology.protein lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Lipoproteins HDL Lipoprotein |
| Zdroj: | European heart journal. 11 |
| ISSN: | 0195-668X |
| Popis: | The early metabolism of cell-derived cholesterol was followed during the interaction of normolipaemic native plasma with cultured cell monolayers labelled to high specific activity with 3H-cholesterol. Kinetic analysis indicated that initial processing involved several prebeta-migrating high-density lipoprotein (HDL) species. A small prebeta species, the initial acceptor, was first converted to a lipoprotein whose composition predicts a discoidal structure. The free cholesterol content of this war then esterified by lecithin: cholesterol acyltransferase, and its cholesterol converted to the alpha mobility of spheroidal mature HDL the binding of apolipoprotein A-II. These studies follow the genesis of HDL in plasma from peripheral cell membrane cholesterol. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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