Disseminated intraparenchymal microgranulomas in the brainstem in central nervous system sarcoidosis
| Autor: | Kozo Kurahashi, Fumiaki Mori, Mitsuomi Kaimori, Makoto Nishie, Koichi Wakabayashi, Chieko Suzuki, Masaya Ogawa |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Pathology
medicine.medical_specialty Sarcoidosis Langhans giant cell Autopsy Pathology and Forensic Medicine Fatal Outcome hemic and lymphatic diseases Humans Medicine Cranial nerve disease Lung Aged Granuloma business.industry Leptomeninges Enterobacteriaceae Infections Neurosarcoidosis Enterobacter aerogenes General Medicine Anatomy medicine.disease Magnetic Resonance Imaging Shock Septic Cranial Nerve Diseases Female Lymph Nodes Neurology (clinical) Astrocytosis medicine.symptom business Brain Stem |
| Zdroj: | Neuropathology. 25:361-364 |
| ISSN: | 1440-1789 0919-6544 |
| DOI: | 10.1111/j.1440-1789.2005.00623.x |
| Popis: | We report a 70-year-old woman with sarcoidosis and multiple cranial nerve palsy. The patient suffered from dysarthria, dysphagia and weakness of the upper and lower extremities and died of sepsis. No abnormalities were noted in brain MRI. At autopsy, numerous epithelioid granulomas with Langhans giant cells were present in the bilateral lungs, including the hilar lymph nodes. The brain had a normal external appearance. Histologically, there were brainstem parenchymal lesions consisting of many microgranulomas, lymphocytic infiltration, activated microglias and astrocytosis. Perivascular lympocytic cuffing was also seen. Neither granulomas nor lymphocytic infiltration were seen in the leptomeninges. The present case was considered to be a peculiar type of neurosarcoidosis, that is, "sarcoid brainstem encephalitis". |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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