Continuing the quest for autoimmunity due to oral metal exposure
| Autor: | Joris Muris, Cees J. Kleverlaan, R.J. Scheper, B.M.E. von Blomberg, Dessy Rachmawati, Albert J. Feilzer, I.M.W. van Hoogstraten, Thomas Rustemeyer |
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| Přispěvatelé: | Pathology, Dermatology, CCA - Immuno-pathogenesis, Dental Material Sciences, Tandheelkundige Materiaalwetenschappen (ORM, ACTA) |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Allergy Immunology Population Autoimmunity medicine.disease_cause SDG 3 - Good Health and Well-being Nickel Hypersensitivity Immunology and Allergy Medicine Humans education Autoantibodies Skin Skin Tests Autoimmune disease education.field_of_study Mouth Skin hypersensitivity business.industry Autoantibody Mercury Middle Aged medicine.disease Anti-thyroid autoantibodies Oral problems Case-Control Studies Female Gold business Palladium Dental Alloys |
| Zdroj: | Autoimmunity, 48(7), 494-501. Informa Healthcare Rachmawati, D, Muris, J, Scheper, R J, Rustemeyer, T, Kleverlaan, C J, Feilzer, A J, von Blomberg, B M E & van Hoogstraten, I M W 2015, ' Continuing the quest for autoimmunity due to oral metal exposure ', Autoimmunity, vol. 48, no. 7, pp. 494-501 . https://doi.org/10.3109/08916934.2015.1033688 |
| ISSN: | 0891-6934 |
| Popis: | Aim: The role of metal exposure in the development of autoimmune disease (AID) is still controversial. Here, we studied the relationship between oral metal exposure, metal allergy and autoimmunity. Methods: A mixed population (n = 78) of non-allergic volunteers, metal-allergic patients and patients with oral problems putatively due to metal alloys was evaluated for oral Ni, Pd, Au and Hg exposure and skin hypersensitivity. Clinical autoimmune parameters were based on medical histories; additionally, serum levels of the four most common autoantibodies were measured. Results: Skin hypersensitivity, as seen mainly for Ni and/or Pd, was not positively associated with autoimmune parameters. In contrast, metal hypersensitive individuals showed an extremely low frequency of thyroid autoantibodies (3% vs 20% in non-hypersensitive controls). Next, the relation between metal exposure and autoimmunity was evaluated in individuals >35 years (n = 58), since from that age on metal exposure had plateaued and was not correlated with age. In this subgroup, oral Ni exposure was associated (p |
| Databáze: | OpenAIRE |
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