Fluconazol plus ofloxacin in prophylaxis of infections in patients with acute leukemia: a comparative study
| Autor: | P. Šajben, E. Tomášik, Danisovicová A, J. Mardiak, T. Minarik, Vladimir Krcmery, T. Trupl |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Ofloxacin Time Factors medicine.drug_class Antibiotics Drug Costs Internal medicine Antimicrobial chemotherapy medicine Humans In patient Fluconazole Acute leukemia business.industry Incidence (epidemiology) Incidence Remission Induction Retrospective cohort study Bacterial Infections Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma Antimicrobial Surgery Survival Rate Leukemia Myeloid Acute Oncology Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 1(4) |
| ISSN: | 0941-4355 |
| Popis: | In a retrospective study the incidence of infections, number of afebrile days, duration of antimicrobial chemotherapy, and cost of antibacterials and antimycotics were compared in two groups of patients. One was a group of 57 patients who received no prophylaxis during induction remission therapy of acute leukemia treated in 1989–1990, the second was a group of 22 patients treated in 1991 where prophylaxis with fluconazol and ofloxacin was administered. For ethical reasons pertaining since 1991, when prophylaxis became mandatory, the study was not randomized. A decrease in the number of febrile days, the cost of antimicrobials and the duration of treatment with antibiotics and antimycotics was observed in the group receiving fluconazol and ofloxacin. |
| Databáze: | OpenAIRE |
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