Short and long term impact of adenotonsillectomy on the immune system
| Autor: | Fábio Pires Santos, Bibiana Fortes, Raimar Weber, Shirley Shizue Nagata Pignatari |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Lymphocyte CD4-CD8 Ratio adenoidectomy Immune system Antigen Adenoidectomy Immunity medicine Humans Prospective Studies Child Tonsillectomy business.industry Hypertrophy Immunity Humoral Immunoglobulin A immune system Lymphatic system medicine.anatomical_structure Immunoglobulin M Otorhinolaryngology Child Preschool Immunoglobulin G Immunology Humoral immunity Adenoids Female business Biomarkers Follow-Up Studies |
| Zdroj: | Brazilian Journal of Otorhinolaryngology. 79(1):28-34 |
| ISSN: | 1808-8694 |
| DOI: | 10.5935/1808-8694.20130006 |
| Popis: | Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. The possible effects of adenotonsillectomy upon the immune system remain controversial. Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children. Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 months after surgery (short term), and 12-14 months after surgery (long term). Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group. Conclusion: This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure. |
| Databáze: | OpenAIRE |
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