Evaluation of dynamic/thiol disulphide balance and ischaemia modified albumin in children with trauma
| Autor: | Sabri Demir, Can İhsan Öztorun, Vildan Selin Çayhan, Müjdem Nur Azili, Aysun Kara Uzun, Hayal Doruk, Ahmet Ertürk, Emrah Şenel, Salim Neselioglu, Ali Güngör, Doğuş Güney, Ülfet Nihal Irdem Köse, Tugba Ornek Demir, Cemil Nural |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Serum Albumin Human Surgical intensive care unit medicine.disease_cause medicine Homeostasis Humans Disulfides Sulfhydryl Compounds Child Serum Albumin Balance (ability) chemistry.chemical_classification business.industry Albumin General Medicine medicine.disease Oxidative Stress chemistry Blunt trauma Anesthesia Thiol Female Ischaemia modified albumin business Biomarkers Penetrating trauma Oxidative stress |
| Zdroj: | International Journal of Clinical Practice. 75 |
| ISSN: | 1742-1241 1368-5031 |
| Popis: | AIM Trauma is the most common cause of death in childhood. Tissue damage, ischaemia-reperfusion injury and inflammatory response are mainly responsible for increasing free oxygen radicals. In this study, we aimed to investigate the use of thiol-disulphide and ischaemia-modified albumin levels as a diagnostic laboratory parameter in trauma children. METHODS Of 202 children, 101 were hospitalised in the paediatric surgical intensive care unit with trauma, and 101 were healthy children. Levels of native thiol (-SH), total thiol (SH + SS), dynamic disulphide (SS), dynamic disulphide (SS)/total thiol (SH + SS), albumin and ischaemic modified albumin (IMA) were measured from the sera of patients and healthy volunteers. For statistical analyses, SPSS 17.0 was used. Mann-Whitney U and paired correlation tests were used where appropriate. P |
| Databáze: | OpenAIRE |
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