Development and performance assessment of an advanced Lucas‐Kanade algorithm for dose mapping of cervical cancer external radiotherapy and brachytherapy plans
| Autor: | Zuzana Vlachová, Paulina Jaskova, Jaroslav Ptáček, Petr Fiala, Václav Novák |
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| Rok vydání: | 2021 |
| Předmět: |
treatment planning
Mean squared error Computer science medicine.medical_treatment Brachytherapy Uterine Cervical Neoplasms Image registration Lucas‐Kanade algorithm computer.software_genre 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Lucas–Kanade method Voxel Hounsfield scale medicine Humans Radiation Oncology Physics Radiology Nuclear Medicine and imaging Pyramid (image processing) deformable image registration Radiation treatment planning Instrumentation Radiation Radiotherapy Planning Computer-Assisted Radiotherapy Dosage 030220 oncology & carcinogenesis Female computer Algorithm Algorithms |
| Zdroj: | Journal of Applied Clinical Medical Physics |
| ISSN: | 1526-9914 |
| Popis: | Purpose The aim of this study was to verify the possibility of summing the dose distributions of combined radiotherapeutic treatment of cervical cancer using the extended Lucas‐Kanade algorithm for deformable image registration. Materials and methods First, a deformable registration of planning computed tomography images for the external radiotherapy and brachytherapy treatment of 10 patients with different parameter settings of the Lucas‐Kanade algorithm was performed. By evaluating the registered data using landmarks distance, root mean square error of Hounsfield units and 2D gamma analysis, the optimal parameter values were found. Next, with another group of 10 patients, the accuracy of the dose mapping of the optimized Lucas‐Kanade algorithm was assessed and compared with Horn‐Schunck and modified Demons algorithms using dose differences at landmarks. Results The best results of the Lucas‐Kanade deformable registration were achieved for two pyramid levels in combination with a window size of 3 voxels. With this registration setting, the average landmarks distance was 2.35 mm, the RMSE was the smallest and the average gamma score reached a value of 86.7%. The mean dose difference at the landmarks after mapping the external radiotherapy and brachytherapy dose distributions was 1.33 Gy. A statistically significant difference was observed on comparing the Lucas‐Kanade method with the Horn‐Schunck and Demons algorithms, where after the deformable registration, the average difference in dose was 1.60 Gy (P‐value: 0.0055) and 1.69 Gy (P‐value: 0.0012), respectively. Conclusion Lucas‐Kanade deformable registration can lead to a more accurate model of dose accumulation and provide a more realistic idea of the dose distribution. |
| Databáze: | OpenAIRE |
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