Inflammation and immune response in acute aortic dissection
| Autor: | Andrea Vecchione, Maria Proietta, Flavia Del Porto, Rachele Amodeo, Trappolini M, Patrizia Cardelli, Fabio Miraldi, Angela Koverech, Vincenzo De Santis, Luigi Tritapepe, Italo Nofroni, G. Aliberti, Fabio Tabacco, Anna Paola Mitterhofer |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Necrosis Lymphocyte Aortic Diseases chemical and pharmacologic phenomena Inflammation Statistics Nonparametric medicine Humans Lymphocyte Count IL-2 receptor aortic dissection cytokiness lymphocyte subpopulations Aged biology business.industry Macrophages Interleukin General Medicine Middle Aged Immunity Innate Aortic Dissection medicine.anatomical_structure Acute Disease Immunology biology.protein Cytokines Female Tumor necrosis factor alpha Antibody medicine.symptom business CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Annals of Medicine. 42:622-629 |
| ISSN: | 1365-2060 0785-3890 |
| DOI: | 10.3109/07853890.2010.518156 |
| Popis: | The aim of our study was to evaluate the lymphocyte subpopulations and the cytokines in the peripheral blood of patients with type-A Stanford acute aortic dissection (AAD group) and to determine whether inflammatory cells are present at the site of aortic dissection.Thirty-five consecutive patients with type-A Stanford dissection were evaluated for haemochrome and lymphocyte subpopulations (CD3+, CD4+, CD8+, CD19+, CD4+CD25+, CD16+CD56+, CD4+CD28-, CD8+CD28-) by flow cytometry. C-reactive protein (CRP), tumour necrosis factor (TNF)-α, interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (IFN-γ), and monocyte chemoattractant protein (MCP)-1 were measured by ELISA. In addition, immunohistochemical staining with cell type-specific antibodies was performed to study the inflammatory cells detected inside the aortic wall.In the AAD group, a significant increase in natural killer (NK) (P = 0.032), B cells (P = 0.022), and CD8+CD28- (P = 0.045) subpopulations was observed, whereas there was a significant decrease in total T lymphocytes (P = 0.004) and T helper fractions (P = 0.005). Moreover, a significant increase in CRP (P0.0001), IL-6 (P0.0001), IL-8 (P0.0001), IL-10 (P0.0001), TNF-α (P0.0001), and MCP-1 (P0.001) was observed; macrophages represented the main population detected inside the media.Our results strongly support the hypothesis of a pivotal role of innate immunity in type-A Stanford AAD. |
| Databáze: | OpenAIRE |
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