Association between phthalate exposure and lower lung function in an urban elderly population: A repeated-measures longitudinal study
| Autor: | Kyoung Nam Kim, Yoon-Hyeong Choi, Bo Eun Lee, Mee Ri Lee, Yun-Chul Hong |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Vital capacity Longitudinal study Urinary system Vital Capacity Phthalic Acids Physiology 010501 environmental sciences 01 natural sciences Pulmonary function testing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Forced Expiratory Volume Republic of Korea Humans Medicine Longitudinal Studies 030212 general & internal medicine lcsh:Environmental sciences Lung function Aged 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Aged 80 and over business.industry Phthalate Repeated measures design Environmental Exposure Middle Aged Confidence interval chemistry Linear Models Environmental Pollutants Female business |
| Zdroj: | Environment International, Vol 113, Iss, Pp 177-183 (2018) |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2018.02.004 |
| Popis: | Background: Lung function is a major predictor of morbidity and mortality. Only a few studies have explored the association between phthalate exposure and lung function. Objective: To evaluate the association between phthalate exposure and lung function in the elderly. Methods: A total of 3 repeated-measures surveys were conducted in 559 elderly individuals aged ≥60 years in Seoul, Korea, at 1-year intervals (2012–2015). During each survey, urinary mono-(2-ethyl-5-hydrohexyl) phthalate (MEHHP) (geometric mean, 15.68 μg/L), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (11.97 μg/L), and mono-n-butyl phthalate (MnBP) (2.09 μg/L) levels were measured; moreover, lung function tests and a structured questionnaire interview were performed. We constructed linear mixed models to assess the association between urinary phthalate metabolite levels and lung function. Results: A doubling of creatinine-adjusted urinary phthalate metabolite levels was inversely associated with forced expiratory volume in 1 s (L) (β = −0.01, 95% confidence interval [CI]: −0.02, 0.004 for MEHHP; β = −0.02, 95% CI: −0.03, −0.01 for MEOHP; β = −0.01, 95% CI: −0.03, −0.003 for MnBP) and forced vital capacity (L) (β = −0.02, 95% CI: −0.03, −0.001 for MEHHP; β = −0.02, 95% CI: −0.03, −0.004 for MEOHP; β = −0.02, 95% CI: −0.03, −0.001 for MnBP). A doubling of creatinine-adjusted MnBP levels was associated with increased rates of annual decline in forced vital capacity (L/year) (β = −0.01, 95% CI: −0.02, −0.001). Conclusions: Urinary phthalate metabolite levels were associated with lower lung function and an increased rate of decline in lung function in an elderly population. Keywords: Elderly, Lung function, Phthalate, Progression analysis, Repeated-measures |
| Databáze: | OpenAIRE |
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