Pharmacological stimulation of chromaffin cell proliferation in the adult adrenal medulla
| Autor: | Laurel A. Ruzicka, Stephen R. Donahue, Arthur S. Tischler, Ronald A. DeLellis |
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| Rok vydání: | 1989 |
| Předmět: |
Pharmacology
medicine.medical_specialty Histology Cell number Pharmacological stimulation Rats Inbred Strains Biology Rats Inbred F344 Rats Autonomic nervous system medicine.anatomical_structure Endocrinology Adrenal Medulla Internal medicine Chromaffin System Chromaffin cell medicine Animals Medullary tumors Neoplastic transformation Adrenal medulla Cell Division Hormone |
| Zdroj: | Archives of Histology and Cytology. 52:209-216 |
| ISSN: | 1349-1717 0914-9465 |
| Popis: | Many strains of rats develop adrenal medullary hyperplasia and/or neoplasia after chronic administration of a wide variety of pharmacologic agents. The same changes may occur spontaneously in the course of aging. Current evidence suggests that chromaffin cell proliferation in adult rats is regulated by a combination of hormonal and neurogenic signals. Drugs associated with adrenal medullary tumors might act directly or indirectly on the hypothalamic-endocrine axis or the autonomic nervous system to stimulate chromaffin cell proliferation through mechanisms which normally adjust cell number to meet physiological needs. The increased cell turnover rate might be a prelude to other events leading to neoplastic transformation. |
| Databáze: | OpenAIRE |
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