Smoking Termination Opportunity for inPatients (STOP): superiority of a course of varenicline tartrate plus counselling over counselling alone for smoking cessation: a 12-month randomised controlled trial for inpatients
| Autor: | Robert Fitridge, Simon A. Koblar, Brian J. Smith, Nadina A Labiszewski, Jim Jannes, Sharon Goldsworthy, Malcolm P Brinn, Antony J. Veale, Adrian Esterman, John Litt, Kristin V Carson, David Edwards, Matthew J. Peters |
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| Přispěvatelé: | Smith, Brian James, Carson, Kristin Veronica, Brinn, Malcolm Philip, Labiszewski, Nadina Ann, Peters, Matthew J, Fitridge, Robert, Koblar, Simon A, Jannes, Jim, Veale, Antony J, Goldsworthy, Sharon J, Litt, John, Edwards, David, Esterman, Adrian Jeffrey |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Counseling Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Population law.invention Varenicline Tartrate Young Adult chemistry.chemical_compound Randomized controlled trial law Quinoxalines Internal medicine medicine Humans In patient Nicotinic Agonists Young adult Varenicline education Aged Inpatients education.field_of_study business.industry Incidence Incidence (epidemiology) Smoking Australia Middle Aged Benzazepines Treatment Outcome chemistry Physical therapy Smoking cessation Female Smoking Cessation business Follow-Up Studies |
| Zdroj: | Thorax. 68:485-486 |
| ISSN: | 1468-3296 0040-6376 |
| DOI: | 10.1136/thoraxjnl-2012-202484 |
| Popis: | Rationale Smoking cessation interventions in outpatient settings have been demonstrated to be cost effective. Given this evidence, we aimed to evaluate the effectiveness of varenicline tartrate plus Quitline-counselling compared with Quitline-counselling alone when initiated in the inpatient setting. Methods Adult patients (18–75 years) admitted with a smoking-related illness to three hospitals, were randomised to receive either 12-weeks of varenicline tartrate plus Quitline-counselling, (n=196) or Quitline-counselling alone, (n=196), with 12-months follow-up. Results For the primary analysis population (intention-to-treat), the proportion of subjects who remained continuously abstinent were significantly greater in the varenicline plus counselling arm (31.1%, n=61) compared with counselling alone (21.4%, n=42; RR 1.45, 95% CI 1.03 to 2.03, p=0.03). Conclusions The combined use of varenicline plus counselling when initiated in the inpatient setting has produced a sustained smoking cessation benefit at 12-months follow-up, indicating a successful opportunistic treatment for smokers admitted with smoking related illnesses. Trial registration http://www.clinicaltrials.gov/ ClinicalTrials.gov identification number: NCT01141855. |
| Databáze: | OpenAIRE |
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