Comparison of single lung transplant with and without the use of cardiopulmonary bypass

Autor: Clare L. Burdett, John H. Dark, James L. Lordan, Stephen Clark, Tanveer Butt
Rok vydání: 2012
Předmět:
Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Adolescent
Hypertension
Pulmonary
medicine.medical_treatment
Respiratory physiology
Postoperative Hemorrhage
Preoperative care
Pulmonary function testing
law.invention
Young Adult
law
medicine
Cardiopulmonary bypass
Humans
Transplantation
Homologous
Lung transplantation
Postoperative Period
Aged
Retrospective Studies
Cardiopulmonary Bypass
Lung
business.industry
Incidence
Original Articles
Middle Aged
respiratory system
medicine.disease
United Kingdom
respiratory tract diseases
Surgery
Treatment Outcome
surgical procedures
operative
medicine.anatomical_structure
Reperfusion Injury
Anesthesia
Female
Fresh frozen plasma
Cardiology and Cardiovascular Medicine
business
Reperfusion injury
Follow-Up Studies
Lung Transplantation
circulatory and respiratory physiology
Zdroj: Interactive CardioVascular and Thoracic Surgery. 15:432-436
ISSN: 1569-9285
1569-9293
DOI: 10.1093/icvts/ivs264
Popis: OBJECTIVES: Many centres avoid using cardiopulmonary bypass (CPB) for lung transplant due to concerns over aggravated lung reperfusion injury and excessive blood loss. We reviewed our 23-years’ experience of single lung transplantation. METHODS: A retrospective review of single lung transplants at our institution (1987–2010), examining differences in allograft function and postoperative complications between CPB and non-bypass (non-CPB) cases. RESULTS: Two hundred and fifty-nine single lung transplants were undertaken. Fifty-three (20.5%) with CPB. There was no difference demographically between the two groups. No difference existed in preoperative PO2/FiO2. At 1 and 24 h, the postoperative PO2/FiO2 ratio was no different (mean 2.95 and 3.24 in non-CPB cases; 3.53 and 3.75 in CPB patients, P= 0.18 and P= 0.34, respectively). Extubation time was not influenced by the use of CPB. Postoperative blood loss was greater in the CPB group. The usage of fresh frozen plasma and platelets was similar (P= 0.64 and 0.41, respectively). More blood was transfused during postoperative care of CPB patients (P= 0.02). CONCLUSIONS: Fears of poor postoperative lung function after CPB appear unfounded. We could detect no difference in function or extubation time. Although the use of CPB increases postoperative bleeding and the need for transfusion, it may be used safely to facilitate lung transplantation.
Databáze: OpenAIRE
Externí odkaz: