Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3
| Autor: | Xiao-Shan Shi, Bin-Gui Wang, Ling-Hong Meng, Xiaoming Li, Xing-Wang Zhou, Dun-Jia Wang, Feng-Yu Du, Xin Li |
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| Rok vydání: | 2020 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Artemisia argyi Magnetic Resonance Spectroscopy Molecular Conformation Bioengineering Human pathogen Microbial Sensitivity Tests medicine.disease_cause Crystallography X-Ray 01 natural sciences Biochemistry Microbiology medicine Escherichia coli Molecular Biology Pathogen biology 010405 organic chemistry Chemistry Terpenes Pathogenic bacteria General Chemistry General Medicine biology.organism_classification Terpenoid 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Micrococcus luteus Artemisia Polyketides Hypocreales Molecular Medicine Antibacterial activity |
| Zdroj: | Chemistrybiodiversity. 17(11) |
| ISSN: | 1612-1880 |
| Popis: | The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 μg/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 μg/mL. |
| Databáze: | OpenAIRE |
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