Evaluation of (-2)proPSA in combination with total PSA and free PSA for the early detection of prostate cancer
| Autor: | Pierre-Jean Lamy, Diego Tosi, Florence Castan, Sylvie Roques, Frédéric Montels, Benoit Leizour, Fabien Nielloud, Xavier Rebillard, Caroline Bascoul-Mollevi |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Population Urology Early detection Prostate cancer Limit of Detection Prostate Biopsy Biomarkers Tumor medicine Health Status Indicators Humans Protein Precursors education Early Detection of Cancer Aged Aged 80 and over education.field_of_study Predictive marker medicine.diagnostic_test Protein Stability business.industry Free psa Prostatic Neoplasms Reproducibility of Results General Medicine Middle Aged Prostate-Specific Antigen medicine.disease medicine.anatomical_structure Blood Preservation business Blood Chemical Analysis Total psa |
| Zdroj: | Annales de biologie clinique. 71:537-544 |
| ISSN: | 0003-3898 |
| DOI: | 10.1684/abc.2013.0894 |
| Popis: | The analytical and clinical validation of new biomarkers for the early detection of prostate is necessary. (-2)proPSA, total PSA and free PSA values are used to calculate a standardized PHI index linked to a higher probability of a positive biopsy in patients with PSA levels between 3-4 and 10 ng/L, the gray zone for prostate cancer diagnosis. The purpose of this study is to validate the analytical performance of the (-2)proPSA and to determine the predictive value of PHI for the early detection of prostate cancer. Analytical performances are correct. It is not necessary to dilute samples before analysis. The stability of (-2)proPSA is good until at least 3 hours at room temperature before centrifugation. The study of the PSAT, PSAL, (-2)proPSA and PHI values in a population of patients consulting for an early prostate cancer diagnosis shows that the index PHI is the most powerful predictive marker of cancer with an area under ROC curve of 0.70, whereas it is only 0.56 for total PSA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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