Status of the development of a vaccine against Mycoplasma bovis
| Autor: | Tracy Prysliak, Jose Perez-Casal, Teresa Maina, Steve Jimbo, Muhammad Suleman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Mycoplasma bovis
0301 basic medicine 040301 veterinary sciences In silico Cattle Diseases Disease Biology medicine.disease_cause Microbiology 0403 veterinary science 03 medical and health sciences Immune system Adjuvants Immunologic Antigen Drug Discovery medicine Animals Mycoplasma Infections Pathogen Antigens Bacterial Vaccines Synthetic General Veterinary General Immunology and Microbiology Public Health Environmental and Occupational Health 04 agricultural and veterinary sciences Antibodies Bacterial Virology Recombinant Proteins 030104 developmental biology Infectious Diseases Bacterial Vaccines Molecular Medicine Cattle |
| Zdroj: | Vaccine. 35:2902-2907 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2017.03.095 |
| Popis: | Mycoplasma bovis is an important pathogen of cattle and, despite numerous efforts an effective vaccine for control of the disease it causes remains elusive. Although we now know more about the biology of this pathogen, information is lacking about appropriate protective antigens, the type of immune response that confers protection and adjuvants selection. The use of conserved recombinant proteins, selected using in silico approaches, as components of a vaccine may be a better choice over bacterin-based vaccines due to the limited protection afforded by them and adverse reactions caused by them. More studies are needed on the characterization of host-pathogen interactions and to elucidate M. bovis products modulating these interactions. These products could be the basis for development of vaccines to control M. bovis infections in dairy farms and feedlots. |
| Databáze: | OpenAIRE |
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