Correlation between vertebral bone microstructure and estimated strength in elderly women: An ex-vivo HR-pQCT study of cadaveric spine
| Autor: | Makoto Era, Makoto Osaki, Toshiyuki Tsurumoto, Narihiro Okazaki, Shuta Yamada, Akihiko Yonekura, Kazuaki Yokota, Yuichiro Nishino, Ko Chiba, Masato Tomita |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Multivariate statistics Histology Physiology Endocrinology Diabetes and Metabolism Finite Element Analysis Osteoporosis 030209 endocrinology & metabolism Correlation 03 medical and health sciences 0302 clinical medicine Cadaver Cortical Bone Image Processing Computer-Assisted medicine Humans Quantitative computed tomography Aged Aged 80 and over Bone mineral Univariate analysis medicine.diagnostic_test business.industry Anatomy medicine.disease Spine 030104 developmental biology medicine.anatomical_structure Cancellous Bone Multivariate Analysis Linear Models Female Cortical bone Tomography X-Ray Computed business Cadaveric spasm |
| Zdroj: | Bone. 120:459-464 |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2018.12.005 |
| Popis: | Purpose A vertebral fracture is the most common complication of osteoporosis, and various factors are involved in its occurrence. The purpose of this study was to investigate the role of trabecular and cortical bone microstructure on vertebral strength using high-resolution peripheral quantitative computed tomography (HR-pQCT). Methods Three female cadaveric spines were investigated (average age: 80.3 years). The whole spine (T1-L4) was scanned by second-generation HR-pQCT at a voxel size of 60.7 μm. Bone microstructure analysis and micro finite element analysis were performed after excluding the upper and lower endplates and posterior elements of a total of 48 vertebrae. Correlations between trabecular and cortical bone microstructure parameters and estimated vertebral strength were analyzed by univariate and multivariate regression models. Results Cortical thickness (Ct.Th) and trabecular thickness (Tb.Th) were strongly correlated with estimated failure load on univariate analysis (r = 0.89, 0.82). Trabecular volumetric bone mineral density (Tb.vBMD), bone volume fraction (BV/TV), trabecular number (Tb.N), and Ct.Th were correlated with estimated failure load on multivariate regression analysis. Conclusions It was suggested that, in addition to trabecular bone (Tb.vBMD, BV/TV, Tb.N), cortical bone (Ct.Th) contributed significantly to vertebral strength in elderly women. |
| Databáze: | OpenAIRE |
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