18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Assessment of Occult Primary Head and Neck Cancers — An Audit and Review of Published Studies
| Autor: | A. Gharpurhy, Michele I. Saunders, David Wellsted, Luke Sonoda, K Goodchild, R. Farrell, Wai-Lup Wong, Catherine Lemon, F. Gollub |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Multimodal Imaging Fluorodeoxyglucose F18 Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Aged Neoplasm Staging Retrospective Studies Aged 80 and over PET-CT Lung medicine.diagnostic_test business.industry Head and neck cancer Cancer Middle Aged Prognosis medicine.disease Occult medicine.anatomical_structure Oncology Head and Neck Neoplasms Positron emission tomography Lymphatic Metastasis Positron-Emission Tomography Carcinoma Squamous Cell Female Radiology Tomography Radiopharmaceuticals Tomography X-Ray Computed Nuclear medicine business Follow-Up Studies |
| Zdroj: | Clinical Oncology. 24:190-195 |
| ISSN: | 0936-6555 |
| DOI: | 10.1016/j.clon.2011.11.001 |
| Popis: | Aims To assess the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with squamous cell and undifferentiated cancer neck nodes and no primary site on conventional assessment. Materials and methods Seventy-eight patients with neck nodal metastases from an unknown primary cancer were studied. PET/CT was carried out in all patients, 1 h after FDG injection. Results Uptake suspicious of an occult primary cancer was found in 46/78 (59.0%) patients. Subsequent investigations confirmed a primary site in the base of the tongue in 14, pharyngeal palatine tonsil in 14, post cricoid in one, lung in one. PET/CT diagnosed primary cancers in 30/78 patients (38.5%); sensitivity, specificity, positive predictive value, negative predictive value: 30/30 (100.0%), 32/48 (66.7%), 30/46 (65.2%), 32/32 (100.0%), respectively. PET/CT detected additional disease in four patients: contralateral nodal disease in two, mediastinal nodal disease in one and liver metastases in one. Conclusions FDG PET/CT is of value in the assessment of patients with occult head and neck primary cancers. However, false-positive results remain a limitation of the investigation. |
| Databáze: | OpenAIRE |
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