CpG-creating Mutations are Costly in Many Human Viruses
| Autor: | Corey Carlson, Samuel Melvin Goodfellow, Nicole Allen, Pleuni S. Pennings, Milo Aviles, Jacky Lo, Rima Singh, Andrew R. Mahoney, Shannel Bermudez, Rebecca L. Melton, Anjani Pradhananga, Annie Shieh, Mordecai Hecht, Sarah Cobey, William Bauer, Francisca L. Catalan, Kellen Hopp, Edgar Castellanos, Ryan Winstead, Hasan Sulaeman, Angeline Katia Chemel, Rosalind M Eggo, Alejandro G. Lopez, Ricky Thu, Adrienne Le, Victoria R. Caudill, Trevor Bedford, E. Geo Pineda, Livia Tran, Andrea López, Fernando G. Lorenzo, Dwayne Evans, Sarina Qin, Gabriela Do Nascimento, Amirhossein Jaberi, Nicole S. Rodrigues, Oana Carja, Katia Koelle, Brittany A. Baker, Gordon T. Luu, Elizabeth J. Winters, Krystal Tran, Christen Kinney, Natalie Fiutek, Scott William Roy, Roland R. Regoes, Katrina A. Lythgoe, Caroline Solis, Jasmeen Kaur, Emily Fryer, Albert Wong, Kaho H. Tisthammer, Derek Lao, Jacob Elliot, E. Deshawn Hopson, Jasmine Sims |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine viruses CpG sites Mutations Viruses Fitness costs Biology medicine.disease_cause 010603 evolutionary biology 01 natural sciences Genome Virus 03 medical and health sciences 0302 clinical medicine medicine Gene Allele frequency Ecology Evolution Behavior and Systematics 030304 developmental biology Genetics 0303 health sciences Mutation Original Paper Transition (genetics) 3. Good health 030104 developmental biology CpG site Animal ecology GenBank 030217 neurology & neurosurgery |
| Zdroj: | Evolutionary Ecology Evolutionary Ecology, 34 |
| ISSN: | 0269-7653 1573-8477 |
| DOI: | 10.1101/702175 |
| Popis: | Mutations can occur throughout the virus genome and may be beneficial, neutral or deleterious. We are interested in mutations that yield a C next to a G, producing CpG sites. CpG sites are rare in eukaryotic and viral genomes. For the eukaryotes, it is thought that CpG sites are rare because they are prone to mutation when methylated. In viruses, we know less about why CpG sites are rare. A previous study in HIV suggested that CpG-creating transition mutations are more costly than similar non-CpG-creating mutations. To determine if this is the case in other viruses, we analyzed the allele frequencies of CpG-creating and non-CpG-creating mutations across various strains, subtypes, and genes of viruses using existing data obtained from Genbank, HIV Databases, and Virus Pathogen Resource. Our results suggest that CpG sites are indeed costly for most viruses. By understanding the cost of CpG sites, we can obtain further insights into the evolution and adaptation of viruses. Evolutionary Ecology, 34 ISSN:0269-7653 ISSN:1573-8477 |
| Databáze: | OpenAIRE |
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