Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications
| Autor: | Andreea D. Lazar, Marieta Costache, Sorina Dinescu, Mihaela Violeta Ghica, Maria Minodora Marin, Mădălina G. Albu-Kaya, Elena Danila, Denisa Ioana Udeanu, Simona-Rebeca Ignat, Ștefania Marin |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Article Subject Biocompatibility Cell Survival Drug Compounding Immunology Capsules 02 engineering and technology 010402 general chemistry 01 natural sciences Drug Delivery Systems Tissue engineering Immunology and Allergy Medicine Animals Humans Rats Wistar Cells Cultured Cell Proliferation Skin Inflammation Wound Healing business.industry Regeneration (biology) Stem Cells Soft tissue General Medicine 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences Flufenamic Acid Rats Flufenamic acid Drug delivery Collagen 0210 nano-technology business Wound healing Burns lcsh:RC581-607 Biomedical engineering medicine.drug Research Article |
| Zdroj: | Journal of Immunology Research, Vol 2019 (2019) Journal of Immunology Research |
| ISSN: | 2314-7156 2314-8861 |
| Popis: | Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications. |
| Databáze: | OpenAIRE |
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